Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15. However, a minority of patients who suffered such adverse drug reaction have NUD...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Pharmacol
Päätekijät: Cao, Minyuan, Yin, Dandan, Qin, Yun, Liao, Fei, Su, Yali, Xia, Xuyang, Gao, Ju, Zhu, Yiping, Zhang, Wei, Shu, Yang, Lu, Xiaoxi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2020
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098961/
https://ncbi.nlm.nih.gov/pubmed/32265697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00267
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