Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy

AIMS: 6-mercaptopurine (6-MP) is used in the treatment of childhood acute lymphoblastic leukaemia (ALL). Its red blood cell (RBC) metabolite concentrations (6-thioguanine [6-TGN] and 6-methylmercaptopurine nucleotides [6-MMPN]) are related to drug response. We investigated the impact of non-genetic...

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Detalhes bibliográficos
Main Authors: Adam de Beaumais, Tiphaine, Fakhoury, May, Medard, Yves, Azougagh, Said, Zhang, Daolun, Yakouben, Karima, Jacqz-Aigrain, Evelyne
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Paediatric Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080646/
https://ncbi.nlm.nih.gov/pubmed/21395650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03867.x
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