Mitotic slippage is determined by p31(comet) and the weakening of the spindle-assembly checkpoint

Mitotic slippage involves cells exiting mitosis without proper chromosome segregation. Although degradation of cyclin B1 during prolonged mitotic arrest is believed to trigger mitotic slippage, its upstream regulation remains obscure. Whether mitotic slippage is caused by APC/C(CDC20) activity that...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Lok, Tsun Ming, Wang, Yang, Xu, Wendy Kaichun, Xie, Siwei, Ma, Hoi Tang, Poon, Randy Y. C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098889/
https://ncbi.nlm.nih.gov/pubmed/32029899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1187-6
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