Cigarette smoke exposure enhances transforming acidic coiled-coil–containing protein 2 turnover and thereby promotes emphysema

Our integrative genomic and functional analysis identified transforming acidic coiled-coil–containing protein 2 (TACC2) as a chronic obstructive pulmonary disease (COPD) candidate gene. Here, we found that smokers with COPD exhibit a marked decrease in lung TACC2 protein levels relative to smokers w...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:JCI Insight
Κύριοι συγγραφείς: Mallampalli, Rama K., Li, Xiuying, Jang, Jun-Ho, Kaminski, Tomasz, Hoji, Aki, Coon, Tiffany, Chandra, Divay, Welty, Starr, Teng, Yaqun, Sembrat, John, Rojas, Mauricio, Zhao, Yutong, Lafyatis, Robert, Zou, Chunbin, Sciurba, Frank, Sundd, Prithu, Lan, Li, Nyunoya, Toru
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2020
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098723/
https://ncbi.nlm.nih.gov/pubmed/31996486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125895
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