Identification of the Intron 22 and Intron 1 Inversions of the Factor VIII Gene in Iraqi Kurdish Patients With Hemophilia A

Hemophilia A (HA) is a severe coagulation disorder affecting 1 in 5000 to 10 000 male births. In severe cases, the most deleterious large DNA rearrangements are inversions of intron 22 (Inv22) and intron 1 (Inv1) of the factor VIII (FVIII) gene. These account for 40% to 50% and 1% to 5% of all causa...

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Veröffentlicht in:Clin Appl Thromb Hemost
Hauptverfasser: Abdulqader, Aveen M. Raouf, Mohammed, Ali Ibrahim, Rachid, Shwan, Ghoraishizadeh, Peyman, Mahmood, Sarwar Noori
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098248/
https://ncbi.nlm.nih.gov/pubmed/31994403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1076029619888293
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