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Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat
Staphylococcus aureus lipase (SAL), a triacylglycerol esterase, is an important virulence factor and may be a therapeutic target for infectious diseases. Herein, we determined the 3D structure of native SAL, the mutated S116A inactive form, and the inhibitor complex using the anti-obesity drug orlis...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7096528/ https://ncbi.nlm.nih.gov/pubmed/32214208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62427-8 |
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