Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling

HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to be revealed. We examined HIF-1α protein expression and the hypoxic condition during mouse osteoarthritis...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Okada, Keita, Mori, Daisuke, Makii, Yuma, Nakamoto, Hideki, Murahashi, Yasutaka, Yano, Fumiko, Chang, Song Ho, Taniguchi, Yuki, Kobayashi, Hiroshi, Semba, Hiroaki, Takeda, Norihiko, Piao, Wen, Hanaoka, Kenjiro, Nagano, Tetsuo, Tanaka, Sakae, Saito, Taku
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096515/
https://ncbi.nlm.nih.gov/pubmed/32214220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62463-4
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