Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

BACKGROUND: Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of articular cartilage. METHODS: Wnt/β-catenin signaling activity wa...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Xuan, Fengjun, Yano, Fumiko, Mori, Daisuke, Chijimatsu, Ryota, Maenohara, Yuji, Nakamoto, Hideki, Mori, Yoshifumi, Makii, Yuma, Oichi, Takeshi, Taketo, Makoto Mark, Hojo, Hironori, Ohba, Shinsuke, Chung, Ung-il, Tanaka, Sakae, Saito, Taku
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880374/
https://ncbi.nlm.nih.gov/pubmed/31771658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-2041-5
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