Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

Visfatin/extracellular-nicotinamide-phosphoribosyltranferase-(eNampt) is a multifaceted adipokine enhanced in type-2-diabetes and obesity. Visfatin/eNampt cause in vitro endothelial dysfunction and vascular inflammation, although whether the same effects are achieved in vivo is unknown. Toll-like re...

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Udgivet i:Sci Rep
Main Authors: Romacho, Tania, Valencia, Inés, Ramos-González, Mariella, Vallejo, Susana, López-Esteban, Miguel, Lorenzo, Oscar, Cannata, Pablo, Romero, Alejandra, San Hipólito-Luengo, Alvaro, Gómez-Cerezo, Jorge F., Peiró, Concepción, Sánchez-Ferrer, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096459/
https://ncbi.nlm.nih.gov/pubmed/32214150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62190-w
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