Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes

The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a key contributor to its lethality. This stromal microenvironment is populated by cancer-associated fibroblasts (CAFs) that interact with cancer cells to drive progression and chemo-resistance. Research has focused...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Pausch, Thomas M., Aue, Elisa, Wirsik, Naita M., Freire Valls, Aida, Shen, Ying, Radhakrishnan, Praveen, Hackert, Thilo, Schneider, Martin, Schmidt, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096431/
https://ncbi.nlm.nih.gov/pubmed/32214219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62416-x
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