Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation

Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC m...

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Pubblicato in:Front Immunol
Autori principali: Gavrilin, Mikhail A., McAndrew, Christian C., Prather, Evan R., Tsai, MuChun, Spitzer, Carleen R., Song, Min-Ae, Mitra, Srabani, Sarkar, Anasuya, Shields, Peter G., Diaz, Philip T., Wewers, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096349/
https://ncbi.nlm.nih.gov/pubmed/32265920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00461
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