Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction

Men and women become infertile with age, but the mechanism of declining male fertility, more specifically, the decrease in in sperm quality, is not well known. Citrate synthase (CS) is a core enzyme of the mitochondrial tricarboxylic acid (TCA) cycle, which directly controls cellular function. Extra...

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Publicat a:Lab Invest
Autors principals: Kang, Woojin, Harada, Yuichirou, Yamatoya, Kenji, Kawano, Natsuko, Kanai, Seiya, Miyamoto, Yoshitaka, Nakamura, Akihiro, Miyado, Mami, Hayashi, Yoshiki, Kuroki, Yoko, Saito, Hidekazu, Iwao, Yasuhiro, Umezawa, Akihiro, Miyado, Kenji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group US 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096335/
https://ncbi.nlm.nih.gov/pubmed/31857692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0353-3
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