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Interleukin-6 (IL-6) Activates the NOTCH1 Signaling Pathway Through E-Proteins in Endometriotic Lesions

CONTEXT: NOTCH signaling is activated in endometriotic lesions, but the exact mechanisms remains unclear. IL-6, which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB in cancer. OBJECTIVE: To study the role of E-proteins in ind...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Song, Yong, Su, Ren-Wei, Joshi, Niraj R, Kim, Tae Hoon, Lessey, Bruce A, Jeong, Jae-Wook, Fazleabas, Asgerally T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096313/
https://ncbi.nlm.nih.gov/pubmed/32119078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgaa096
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