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Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility

In mammalian reproduction, implantation is one of the most critical events. Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy losses in women. Our laboratory has previously reported that inhibition of Notch signaling results in impaired decidualizati...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Su, Ren-Wei, Strug, Michael R., Jeong, Jae-Wook, Miele, Lucio, Fazleabas, Asgerally T.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776514/
https://ncbi.nlm.nih.gov/pubmed/26858409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520441113
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