The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Na(v)1.1 in addition to Na(v)1.6

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in neurons. The human genome includes ten human VGSC α-subunit genes, SCN(X)A, encoding Na(v)1.1–1.9 plus Na(x). To understand the unique role that each VGSC plays in normal and pathophysiol...

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Publicado en:Neurosci Lett
Autores principales: Denomme, Nicholas, Lukowski, April L., Hull, Jacob M., Jameson, Margaret B., Bouza, Alexandra A., Narayan, Alison R.H., Isom, Lori L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096269/
https://ncbi.nlm.nih.gov/pubmed/32114117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.134853
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