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An adenoviral vector-based mucosal vaccine is effective in protection against botulism
A replication-incompetent adenoviral vector encoding the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C) was evaluated as a mucosal vaccine against botulism in a mouse model. Single intranasal inoculation of the adenoviral vector elicited a high level of H(C)50-specific IgG,...
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| Veröffentlicht in: | Gene Ther |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7094725/ https://ncbi.nlm.nih.gov/pubmed/19129860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2008.181 |
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