Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine

Botulinum neurotoxins cause botulism, a neuroparalytic disease in humans and animals. We constructed a replication-incompetent adenovirus encoding a synthesized codon-optimized gene for expression of the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C). This recombinant human...

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Autori principali: Zeng, Mingtao, Xu, Qingfu, Elias, MD, Pichichero, Michael E., Simpson, Lance L., Smith, Leonard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077857/
https://ncbi.nlm.nih.gov/pubmed/17897756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.08.035
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