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Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine
Botulinum neurotoxins cause botulism, a neuroparalytic disease in humans and animals. We constructed a replication-incompetent adenovirus encoding a synthesized codon-optimized gene for expression of the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C). This recombinant human...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2077857/ https://ncbi.nlm.nih.gov/pubmed/17897756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.08.035 |
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