Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling

RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to negatively regulate Toll-like receptor 4 (TLR4) signaling through nuclear factor κB (NF-κB) in lung epithelial cells. Here we show that RUNX1 regulates TLR1/2 and TLR4 signaling and inflammatory cytokine productio...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Bellissimo, Dana C., Chen, Chia-hui, Zhu, Qin, Bagga, Sumedha, Lee, Chung-Tsai, He, Bing, Wertheim, Gerald B., Jordan, Martha, Tan, Kai, Worthen, G. Scott, Gilliland, D. Gary, Speck, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094023/
https://ncbi.nlm.nih.gov/pubmed/32208490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000785
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