Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway

Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is a flavonoid-like compound known to have antioxidant effects. As oxidative injury plays a vital role in CDD...

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Publicat a:Front Pharmacol
Autors principals: Fan, Xiaoye, Wei, Wei, Huang, Jingbo, Liu, Xingkai, Ci, Xinxin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093647/
https://ncbi.nlm.nih.gov/pubmed/32256355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00264
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