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Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics
Recombinant protein containing one heptad-repeat 1 (HR1) segment and one HR2 segment of the HIV-1 gp41 (HR1–HR2) has been shown to fold into thermally stable six-helix bundle, representing the fusogenic core of gp41. In this study, we have used the fusogenic core as a scaffold to design HIV-1 fusion...
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| Pubblicato in: | Biochem Biophys Res Commun |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier Inc.
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7092902/ https://ncbi.nlm.nih.gov/pubmed/15913557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2005.05.037 |
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