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Structural Origin of the Large Redox-Linked Reorganization in the 2-Oxoglutarate Dependent Oxygenase, TauD

2-Oxoglutarate (2OG)-dependent oxygenases catalyze a wide range of chemical transformations via C─H bond activation. Prior studies raised the question of whether substrate hydroxylation by these enzymes occurs via a hydroxyl rebound or alkoxide mechanism and highlighted the need to understand the th...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: John, Christopher W., Hausinger, Robert P., Proshlyakov, Denis A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092798/
https://ncbi.nlm.nih.gov/pubmed/31475523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b07493
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