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Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines

1-Substituted and 1,1-disubstituted tetrahydro-β-carbo-lines undergo sodium periodate oxidative ring expansion in the presence of formaldehyde and other aldehydes to form 5,6-dihydro-7H-1,4-methanobenzo[e][1,4]diazonine-2,7(3H)-diones in 30–81% yield. In most cases, the reaction to form this new 6/8...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Leas, Derek A., Dong, Yuxiang, Garrison, Jered C., Wang, Xiaofang, Ezell, Edward L., Stack, Douglas E., Vennerstrom, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092372/
https://ncbi.nlm.nih.gov/pubmed/31904963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b03402
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