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Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus

Iron is an essential element for cellular functions, including those of neuronal cells. However, an imbalance of iron homeostasis, such as iron overload, has been observed in several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Iron overload causes neuronal toxi...

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Publicat a:Cell Death Dis
Autors principals: Lee, Dong Gil, Kam, Min Kyoung, Lee, Sang-Rae, Lee, Hong Jun, Lee, Dong-Seok
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090063/
https://ncbi.nlm.nih.gov/pubmed/32205843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2402-7
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