Peroxiredoxin 5 Inhibits Glutamate-Induced Neuronal Cell Death through the Regulation of Calcineurin-Dependent Mitochondrial Dynamics in HT22 Cells

Glutamate is an essential neurotransmitter in the central nervous system (CNS). However, high glutamate concentrations can lead to neurodegenerative diseases. A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca(2+) influx and dynamin-related protein...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Kim, Mi Hye, Lee, Hong Jun, Lee, Sang-Rae, Lee, Hyun-Shik, Huh, Jae-Won, Bae, Yong Chul, Lee, Dong-Seok
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766699/
https://ncbi.nlm.nih.gov/pubmed/31358548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00148-19
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