CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. The mechanism, however, is only partially resolved, and it is unclear if it is conserved among the four remodeller families. Here we use single-molecule assays to examine the mechanism of action of CHD4, which is p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhong, Yichen, Paudel, Bishnu P., Ryan, Daniel P., Low, Jason K. K., Franck, Charlotte, Patel, Karishma, Bedward, Max J., Torrado, Mario, Payne, Richard J., van Oijen, Antoine M., Mackay, Joel P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090039/
https://ncbi.nlm.nih.gov/pubmed/32251276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15183-2
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