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All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators
The proteasome is an essential enzyme complex in cells whose main responsibility is to degrade proteins. Proteins can be degraded through either a ubiquitin-dependent or -independent mechanism by the proteasome. A variety of small molecules have been discovered that can increase the rate of protein...
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| Veröffentlicht in: | ACS Pharmacol Transl Sci |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2018
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7088911/ https://ncbi.nlm.nih.gov/pubmed/32219211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00042 |
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