Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function

Hydrogen peroxide (H(2)O(2)) is a key redox intermediate generated within cells. Existing probes for H(2)O(2) have not solved the problem of detection of the ultra-low concentrations of the oxidant: these reporters are either not sensitive enough, or pH-dependent, or insufficiently bright, or not fu...

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發表在:Cell Metab
Main Authors: Pak, Valeriy V., Ezeriņa, Daria, Lyublinskaya, Olga G., Pedre, Brandán, Tyurin-Kuzmin, Pyotr A., Mishina, Natalie M., Thauvin, Marion, Young, David, Wahni, Khadija, Gache, Santiago Agustín Martínez, Demidovich, Alexandra D., Ermakova, Yulia G., Maslova, Yulia D., Shokhina, Arina G., Eroglu, Emrah, Bilan, Dmitry S., Bogeski, Ivan, Michel, Thomas, Vriz, Sophie, Messens, Joris, Belousov, Vsevolod V.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088435/
https://ncbi.nlm.nih.gov/pubmed/32130885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.02.003
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