Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function

Hydrogen peroxide (H(2)O(2)) is a key redox intermediate generated within cells. Existing probes for H(2)O(2) have not solved the problem of detection of the ultra-low concentrations of the oxidant: these reporters are either not sensitive enough, or pH-dependent, or insufficiently bright, or not fu...

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Udgivet i:Cell Metab
Main Authors: Pak, Valeriy V., Ezeriņa, Daria, Lyublinskaya, Olga G., Pedre, Brandán, Tyurin-Kuzmin, Pyotr A., Mishina, Natalie M., Thauvin, Marion, Young, David, Wahni, Khadija, Gache, Santiago Agustín Martínez, Demidovich, Alexandra D., Ermakova, Yulia G., Maslova, Yulia D., Shokhina, Arina G., Eroglu, Emrah, Bilan, Dmitry S., Bogeski, Ivan, Michel, Thomas, Vriz, Sophie, Messens, Joris, Belousov, Vsevolod V.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088435/
https://ncbi.nlm.nih.gov/pubmed/32130885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.02.003
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