Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy

BACKGROUND: Autophagy has been reported to play a pivotal role on the replication of various RNA viruses. In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated anti-HCV effects of an autophagic proteolysis inhibitor, chloroquine. METHODS: In...

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Detalhes bibliográficos
Publicado no:J Gastroenterol
Main Authors: Mizui, Tomokazu, Yamashina, Shunhei, Tanida, Isei, Takei, Yoshiyuki, Ueno, Takashi, Sakamoto, Naoya, Ikejima, Kenichi, Kitamura, Tsuneo, Enomoto, Nobuyuki, Sakai, Tatsuo, Kominami, Eiki, Watanabe, Sumio
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2009
Assuntos:
Original Article—Liver, Pancreas, and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088329/
https://ncbi.nlm.nih.gov/pubmed/19760134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-009-0132-9
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