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Glycosylated human interleukin-1α, neoglyco IL-1α, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution
In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1α. NeuAc-coupled IL-1α (NeuAc-IL-1α) exhibited reduced activities in vitro and...
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| 發表在: | Glycoconj J |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Kluwer Academic Publishers-Plenum Publishers
2000
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7088040/ https://ncbi.nlm.nih.gov/pubmed/11294501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1007181929405 |
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