Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome associated coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target. Recombinant 3CL(pro) was expressed in Pichia pastoris GS115 as a 42 kDa protein that displayed a K (m) of 15 ± 2 μM with Dabcyl-KTS...

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Bibliographic Details
Published in:Biotechnol Lett
Main Authors: Nguyen, Thi Thanh Hanh, Woo, Hye-Jin, Kang, Hee-Kyoung, Nguyen, Van Dao, Kim, Young-Min, Kim, Do-Won, Ahn, Sul-Ah, Xia, Yongmei, Kim, Doman
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2012
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7087583/
https://ncbi.nlm.nih.gov/pubmed/22350287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10529-011-0845-8
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