A Novel Neutralizing Antibody Targeting a Unique Cross-Reactive Epitope on the hi Loop of Domain II of the Envelope Protein Protects Mice against Duck Tembusu Virus

The Flavivirus E protein induces protective immunity, and its Abs cause serious problems for serodiagnosis because of the difficulty in differentiating cross-reactive Abs. Moreover, cross-reactive Abs may increase disease severity after secondary Flavivirus infections via Ab-dependent enhancement. C...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Chen, Xueming, Li, Chenxi, Lin, Weiwei, Li, Tongtong, Li, Xiaojun, Bai, Xiaofei, Wulin, Shaozhou, Zhang, Qingshan, Li, Shuang, Liu, Ming, Liu, Jyung-Hurng, Zhang, Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2020
Schlagworte:
Infectious Disease and Host Response
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086385/
https://ncbi.nlm.nih.gov/pubmed/32132180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901352
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