Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis

Rationale: Hyperlipidemia is a major risk factor of atherosclerosis and cardiovascular diseases (CVD). As a standard-of-care approach for hyperlipidemia, statins only reduce the risk of coronary artery disease by 20-40%, underscoring the importance of identifying molecular pathways for the design of...

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Publicado en:Theranostics
Autores principales: Zhang, Tianpeng, Shi, Hongtao, Liu, Ningning, Tian, Jing, Zhao, Xiaoling, Steer, Clifford J., Han, Qinghua, Song, Guisheng
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086368/
https://ncbi.nlm.nih.gov/pubmed/32226531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.39578
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