Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells

In this report, we demonstrated that inorganic arsenic (iAs) induces generation of the cancer stem-like cells (CSCs) through Nrf2-dependent HIF1α activation, and the subsequent metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis in epithelial cells. Methods: Genome-wid...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Bi, Zhuoyue, Zhang, Qian, Fu, Yao, Wadgaonkar, Priya, Zhang, Wenxuan, Almutairy, Bandar, Xu, Liping, Rice, M'Kya, Qiu, Yiran, Thakur, Chitra, Chen, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086359/
https://ncbi.nlm.nih.gov/pubmed/32226544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.42903
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