Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

BACKGROUND: Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expression profile of the inhaled PDE4-inhibitor CHF60...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Govoni, Mirco, Bassi, Michele, Vezzoli, Stefano, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Petruzzelli, Stefano, Jellema, Gera L., Afolabi, Ebenezer K., Colgan, Brendan, Leaker, Brian, Kornmann, Oliver, Beeh, Kai Michael, Watz, Henrik, Singh, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085203/
https://ncbi.nlm.nih.gov/pubmed/32197620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-020-1329-y
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