Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents

Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation. Deletion of five amino acids (ELREA) in exon 19 and mutational change from leucine to arginine at po...

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Bibliografiske detaljer
Udgivet i:	Int J Mol Sci
Main Authors:	Minnelli, Cristina, Laudadio, Emiliano, Mobbili, Giovanna, Galeazzi, Roberta
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2020
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7084708/ https://ncbi.nlm.nih.gov/pubmed/32138321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051721
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Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents

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