Caricamento...

Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents

Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation. Deletion of five amino acids (ELREA) in exon 19 and mutational change from leucine to arginine at po...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Minnelli, Cristina, Laudadio, Emiliano, Mobbili, Giovanna, Galeazzi, Roberta
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084708/
https://ncbi.nlm.nih.gov/pubmed/32138321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051721
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !