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Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a leading cause of cancer death. The multikinase inhibitor sorafenib is widely used for systemic therapy in advanced HCC. Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion...

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Publicat a:Int J Mol Sci
Autors principals: Leineweber, Can G., Pietzner, Anne, Zhang, Ingrid W., Blessin, Usha B., Rothe, Michael, Schott, Eckart, Schebb, Nils H., Weylandt, Karsten H.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084535/
https://ncbi.nlm.nih.gov/pubmed/32182938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051875
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