Tetraspanin-6 negatively regulates exosome production

Exosomes, extracellular vesicles (EVs) of endosomal origin, emerge as master regulators of cell-to-cell signaling in physiology and disease. Exosomes are highly enriched in tetraspanins (TSPNs) and syndecans (SDCs), the latter occurring mainly in proteolytically cleaved form, as membrane-spanning C-...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ghossoub, Rania, Chéry, Marion, Audebert, Stéphane, Leblanc, Raphael, Egea-Jimenez, Antonio Luis, Lembo, Frédérique, Mammar, Sarah, Le Dez, Flavien, Camoin, Luc, Borg, Jean-Paul, Rubinstein, Eric, David, Guido, Zimmermann, Pascale
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084133/
https://ncbi.nlm.nih.gov/pubmed/32108028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922447117
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