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Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme

Clostridioides difficile is a Gram-positive, pathogenic bacterium and a prominent cause of hospital-acquired diarrhea in the United States. The symptoms of C. difficile infection are caused by the activity of three large toxins known as toxin A (TcdA), toxin B (TcdB), and the C. difficile transferas...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sheedlo, Michael J., Anderson, David M., Thomas, Audrey K., Lacy, D. Borden
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084131/
https://ncbi.nlm.nih.gov/pubmed/32123082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920555117
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