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Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution

Clostridioides difficile is a common cause of nosocomial diarrhoea. Toxins TcdA and TcdB are considered to be the main virulence factors and are encoded by the PaLoc region, while the binary toxin encoded in the CdtLoc region also contributes to pathogenicity. Variant toxinotypes reflect the genetic...

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Detalhes bibliográficos
Publicado no:Microb Genom
Main Authors: Janezic, Sandra, Dingle, Kate, Alvin, Joseph, Accetto, Tomaž, Didelot, Xavier, Crook, Derrick W., Lacy, D. Borden, Rupnik, Maja
Formato: Artigo
Idioma:Inglês
Publicado em: Microbiology Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660249/
https://ncbi.nlm.nih.gov/pubmed/33030421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mgen.0.000449
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