Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts

Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we re...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Choi, John Y., Eskandari, Siawosh K., Cai, Songjie, Sulkaj, Ina, Assaker, Jean Pierre, Allos, Hazim, AlHaddad, Juliano, Muhsin, Saif A., Alhussain, Eman, Mansouri, Amr, Yeung, Melissa Y., Seelen, Marc A. J., Kim, Hye-Jung, Cantor, Harvey, Azzi, Jamil R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084119/
https://ncbi.nlm.nih.gov/pubmed/32111690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918950117
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