Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

Recombinant immunotoxins (RITs) are chimeric proteins composed of an Fv and a protein toxin being developed for cancer treatment. The Fv brings the toxin to the cancer cell, but most of the RITs do not reach the tumor and are removed by other organs. To identify cells responsible for RIT removal, an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Xui-Fen, Wei, Junxia, Zhou, Qi, Molitoris, Bruce A., Sandoval, Ruben, Kobayashi, Hisataka, Okada, Ryuhei, Nagaya, Tadanobu, Karim, Baktiar, Butcher, Donna, Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084118/
https://ncbi.nlm.nih.gov/pubmed/32123080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919038117
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