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Frameshifting preserves key physicochemical properties of proteins

Frameshifts in protein coding sequences are widely perceived as resulting in either nonfunctional or even deleterious protein products. Indeed, frameshifts typically lead to markedly altered protein sequences and premature stop codons. By analyzing complete proteomes from all three domains of life,...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bartonek, Lukas, Braun, Daniel, Zagrovic, Bojan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084103/
https://ncbi.nlm.nih.gov/pubmed/32127487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911203117
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