Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification

OBJECTIVE: Calcification of atherosclerotic plaque is traditionally associated with increased cardiovascular event risk; however, recent studies have found increased calcium density to be associated with more stable disease. HMG-CoA reductase inhibitors or “statins” reduce cardiovascular events. Inv...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Healy, Abigail, Berus, Joshua M., Christensen, Jared L., Lee, Cadence, Mantsounga, Chris, Dong, Willie, Watts, Jerome P., Assali, Maen, Ceneri, Nicolle, Nilson, Rachael, Neverson, Jade, Wu, Wen-Chih, Choudhary, Gaurav, Morrison, Alan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082877/
https://ncbi.nlm.nih.gov/pubmed/31996022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313832
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