A Mouse Model of Chemotherapy-Related Cognitive Impairments Integrating the Risk Factors of Aging and APOE4 Genotype

Some cancer survivors experience marked cognitive impairment, referred to as cancer-related cognitive impairment (CRCI). CRCI has been linked to the genetic factor APOE4, the strongest genetic risk factor for Alzheimer’s disease (AD). We used APOE knock-in mice to test whether the relationship betwe...

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Détails bibliographiques
Publié dans:Behav Brain Res
Auteurs principaux: Demby, Tamar C., Rodriguez, Olga, McCarthy, Camryn W., Lee, Yi-Chien, Albanese, Christopher, Mandelblatt, Jeanne, Rebeck, G. William
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082850/
https://ncbi.nlm.nih.gov/pubmed/32027870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2020.112534
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