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Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice

Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates in patients with cardiometabolic disease. Glucocorticoids are primary stress hormones that regulate homeostasis through two nuclear receptors, the glucocorticoid receptor (GR) and mineralocorticoid recep...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Oakley, Robert H., Cruz-Topete, Diana, He, Bo, Foley, Julie F., Myers, Page H., Xu, Xiaojiang, Gomez-Sanchez, Celso E., Chambon, Pierre, Willis, Monte S., Cidlowski, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082727/
https://ncbi.nlm.nih.gov/pubmed/30992401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau9685
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