Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry

IMPORTANCE: Hereditary transthyretin (TTR) amyloid cardiomyopathy (hATTR-CM) due to the TTR V122I variant is an autosomal-dominant disorder that causes heart failure in elderly individuals of African ancestry. The clinical associations of carrying the variant, its effect in other African ancestry po...

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Bibliographic Details
Published in:JAMA
Main Authors: Damrauer, Scott M., Chaudhary, Kumardeep, Cho, Judy H., Liang, Lusha W., Argulian, Edgar, Chan, Lili, Dobbyn, Amanda, Guerraty, Marie A., Judy, Renae, Kay, Jenna, Kember, Rachel L., Levin, Michael G., Saha, Aparna, Van Vleck, Tielman, Verma, Shefali S., Weaver, JoEllen, Abul-Husn, Noura S., Baras, Aris, Chirinos, Julio A., Drachman, Brian, Kenny, Eimear E., Loos, Ruth J. F., Narula, Jagat, Overton, John, Reid, Jeffrey, Ritchie, Marylyn, Sirugo, Giorgio, Nadkarni, Girish, Rader, Daniel J., Do, Ron
Format: Artigo
Language:Inglês
Published: American Medical Association 2019
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081752/
https://ncbi.nlm.nih.gov/pubmed/31821430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.17935
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