Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

BACKGROUND: In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic...

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發表在:Genome Med
Main Authors: Wierzbinska, Justyna A., Toth, Reka, Ishaque, Naveed, Rippe, Karsten, Mallm, Jan-Philipp, Klett, Lara C., Mertens, Daniel, Zenz, Thorsten, Hielscher, Thomas, Seifert, Marc, Küppers, Ralf, Assenov, Yassen, Lutsik, Pavlo, Stilgenbauer, Stephan, Roessner, Philipp M., Seiffert, Martina, Byrd, John, Oakes, Christopher C., Plass, Christoph, Lipka, Daniel B.
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081711/
https://ncbi.nlm.nih.gov/pubmed/32188505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00724-7
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