Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues

[Image: see text] Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway of isoprenoid biosynthesis is essential to the causative agent of the plague, Yersini...

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Pubblicato in:ACS Omega
Autori principali: Ball, Haley S., Girma, Misgina, Zainab, Mosufa, Riley, Honoria, Behrendt, Christoph T., Lienau, Claudia, Konzuch, Sarah, Avelar, Leandro A. A., Lungerich, Beate, Soojhawon, Iswarduth, Noble, Schroeder M., Kurz, Thomas, Couch, Robin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081406/
https://ncbi.nlm.nih.gov/pubmed/32201804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b04171
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